Introduction to Microneedling & PRP
Microneedling and PRP have become cornerstone in-office therapies for hair regeneration. Microneedling induces controlled microtrauma that stimulates wound-healing cascades and growth factor release; PRP concentrates autologous growth factors to enhance tissue repair and follicular activation. When combined, they create synergistic effects that improve hair density and thickness in many patients.
The Science Behind the Treatments
Microneedling increases expression of VEGF and β-catenin signaling pathways. PRP delivers concentrated PDGF, TGF-β, and VEGF, which promote angiogenesis and follicle repair. Clinical trials through 2024 show consistent improvements in hair count and thickness with combined therapy versus monotherapy.
Standardized Treatment Protocols
Typical protocol: microneedling (0.5–1.5 mm depth depending on scalp area) followed by PRP application/injection every 4 weeks for 3–4 sessions, then maintenance every 3–6 months. Pre-procedure planning includes stopping anticoagulants (as appropriate), a CBC, and infection screening.
Combining PRP with Topicals & LLLT
Layer therapies for best results: topical minoxidil or peptide serums post-procedure (after recommended healing period), daily LLLT adjuncts, and optimized nutrition. Combination approaches consistently outperform single modalities in head-to-head analyses.
Aftercare and Minimizing Downtime
Expect transient redness and mild soreness for 24–72 hours. Recommend gentle cleansing, avoidance of harsh chemicals for 7–10 days, and topical antibiotics only if clinically indicated. Encourage sleep and nutrition support for wound healing.
What to Expect: Timeline & Results
Initial shedding may occur followed by visible regrowth at 3 months, with measurable improvements at 6 months. Best outcomes are typically seen when microneedling + PRP are combined with systemic optimization (iron, vitamin D) and daily adjuncts.
Risks, Contraindications & Costs
Risks are low but include infection, temporary scabbing, and inconsistent results. Contraindications include platelet dysfunction, active scalp infection, or unrealistic expectations. Costs vary by clinic and region; discuss candidly with patients.