What Are DHT-Blocking Shampoos?
DHT-blocking shampoos are topical products formulated to reduce the effects of dihydrotestosterone (DHT)—the main hormone responsible for androgenetic alopecia. DHT causes follicles to miniaturize over time, resulting in thinner, weaker strands. These shampoos work by delivering active ingredients directly to the scalp, reducing buildup and promoting follicular health.
Unlike oral medications such as finasteride, DHT-blocking shampoos target the scalp locally and are generally considered safe for both men and women.
Top Ingredients That Block DHT
Look for shampoos containing saw palmetto, ketoconazole, caffeine, and green tea extract. These compounds inhibit 5-alpha-reductase—the enzyme that converts testosterone to DHT. In a 2023 study published in the International Journal of Trichology, 1% ketoconazole shampoo demonstrated a 17% reduction in scalp DHT after 8 weeks of use.
Additionally, caffeine enhances microcirculation and may counteract DHT’s miniaturizing effects by stimulating follicle energy metabolism.
Best DHT-Blocking Shampoos in 2025
Dermatologists highlight three standout products this year:
1. Revita Hair Stimulating Shampoo
Combines ketoconazole, caffeine, and biotin to reduce DHT and strengthen follicles. Clinically tested to increase hair density after 90 days of regular use.
2. Nioxin System 2 Cleanser
Ideal for fine, thinning hair. Contains peppermint oil for scalp refreshment and antioxidant botanicals for follicular defense.
3. Botanical DHT-Defense Shampoo
Features saw palmetto and pumpkin seed extract—natural inhibitors proven to support healthy growth without irritation.
How to Use Effectively
Apply the shampoo to a wet scalp, massaging for 1–2 minutes to enhance absorption before rinsing. For optimal results, alternate with a hydrating conditioner and use 3–4 times weekly. Pairing with minoxidil can further accelerate visible regrowth.
Dermatologist Takeaway
“Shampoos alone rarely reverse advanced hair loss,” says Dr. Jonathan Reyes. “But when used as part of a complete regimen—including minoxidil, nutrition, and stress control—they significantly enhance scalp health and slow DHT’s effects.”
